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The stool is mixed with sterile saline and delivered through a nasogastric tube colono-scopically, or by retention enema. A validated HPLCmethod for the monitoring of thiopurine metabolites in whole blood in paediatricpatients with inflammatory bowel disease. Care is taken to decrease serum sodium levels only 0.5–1mEq/kg/hto avoid cerebral edema.

Olshansky B, Rosenfeld LE, Warner AL, Solomon AJ, O’Neill G, Sharma A,et al. The calculations from all thedata collected for this study showed that the risk of spinal manipulationcausing a clinically worsened disk herniation or CES in a patient present-ing with LDH was estimated to be less than 1 in 3.7 million. The magnitude of individual lipid and lipoproteinresponses may be influenced by the severity and type of underlyinglipid abnormality.68 In a dose-escalation study, ER formulationof niacin with monthly 500 mg increases in dose, there wereincremental changes in LDL, HDL, and triglycerides in the doserange of 0.5–2 g daily69 (Table 10)

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Section 7.3 summarizescommon methods that are used to assess renal function and tox-icity in clinical settings and in the whole animal.

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